Human clinical trial reveals verapamil as an effective Type 1 diabetes therapy
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Human clinical trial reveals verapamil as an effective Type 1 diabetes therapy

September 8, 2019


For the millions of people living with
diabetes worldwide, a UAB study brings exciting news. The first successful
treatment to boost the body’s own insulin production. Researchers and
patient advocates call it a breakthrough better yet the drug is already on the
market and it’s cheap a 30 year old generic blood pressure medicine called
verapamil so what’s that got to do with diabetes? the answer lies deep in the
pancreas that’s where specialized cells called
beta cells produce insulin releasing it into the bloodstream to control blood
sugar levels in people with diabetes beta cells can’t
produce enough insulin over time they die and rising blood sugar levels damage
the heart kidneys eyes and more insulin injections and other medications can
lower blood sugar but nothing prevents beta cell loss until now many years of
research pointed UAB scientists to verapamil a drug widely used to treat
high blood pressure in their lab tests Verapamil protected beta cells but
would it work in humans? The answer according to the new UAB study is yes
adults with newly diagnosed type 1 diabetes were given verapamil tablets in
addition to their regular insulin injections the result was they produced
more of their own insulin limiting their need for injected insulin these
groundbreaking results could help patients better manage type 1 diabetes
meanwhile UAB researchers continue their work toward truly disease modifying
diabetes therapies they’re also hoping to launch human studies of Verapamil
and different diabetes populations follow their work at uab.edu/diabetes

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