“Cerebral Autoregulation” by Lisa DelSignore for OPENPediatrics
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“Cerebral Autoregulation” by Lisa DelSignore for OPENPediatrics

August 31, 2019


Cerebral Autoregulation by Dr. Lisa DelSignore Next, I just want to talk
about the relationship between cerebral blood flow and
cerebral perfusion pressure. Knowing that cerebral
blood flow is going to be what’s actually
delivering nutrients to the brain and is separate
from cerebral blood volume. However, if you have an
increasing cerebral blood flow, you’ll likely have an increasing
cerebral blood volume, which will also
potentially increase your intracranial pressure. But you can see here the
concept of autoregulation in the brain, in that,
along a wide range of cerebral perfusion pressures,
your cerebral blood flow stays relatively constant,
until you hit the extremes either on
the left side of the curve or the right side
of the curve where the brain is unable
to compensate. On the right side
of the curve, you can think of this as the
cerebral perfusion pressure is so high that now the cerebral
blood flow just astronomically starts to increase due
to overwhelming volume. And on the left
side here, you can see that as the cerebral
perfusion pressure drops between a critical level
your cerebral blood flow drops dramatically as well. And we can think about this
in the setting of ischemia and probably putting
the brain at a high risk for hypoxia and cell death.

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